Yes, it would. I've seen it occur a number of times back in my home world. One day you're normal, the next you can -- oh, I don't know, make anything explode with just a touch of your hands?

[Less so a random example, and more witness to another's experience.]

Of course the mutation doesn't just happen out of the blue. It usually has a trigger, be it from inside the body or the surroundings of the world. I research the latter.